Home / Knowledge Center

Different Molecular Weights HA & Your Skin

The Structure of Hyaluronic Acid

Although hyaluronic acid has “acid” in its name, but it’s not an exfoliating ingredient. The highest amount of hyaluronic acid is found in our skin. When it is not connected to other molecules, it binds to water. Its consistency and the fact that it can be used for all types of skin, making hyaluronic acid an excellent moisturizer. Since hyaluronic acid is one of the most hydrophilic (water-loving) molecules, it is often referred to as “nature’s moisturizer.” As there is less hyaluronic acid in the aging skin than in the younger skin so if you want to reserve your younger look, then you should make up for the loss of hyaluronic acid in your body.

It’s a main component of the extracellular matrix. This matrix is the gel-like substance that encircles your skin cells. Proteins, collagen, elastin and other glycosaminoglycans are also parts of this substance. Glycosaminoglycans is a member of the family of polysaccharides, or carbohydrates, of which hyaluronic acid is a component. Hyaluronic acid and other glycosaminoglycans help improve skin elasticity, cell metabolism and regeneration.

The skin of your lips is primarily composed of connective tissue, consisting of hyaluronic acid and collagen. They give shape and fullness to the lips. Hyaluronic acid binds to water and it creates a gel-like liquid that keeps your lips nourished and healthy.

Hyaluronic acid is also concentrated inside the eyeball. It gives the fluid of the eye a gel-like property. This gel serves to fill the eyes with nutrients thus keeping them healthy.

Different Molecular Sizes of Hyaluronic Acid

Hyaluronic acid has different molecular sizes and it is very important to differentiate among them as they penetrate into different levels of the skin. The two most important types are high molecular weight and low molecular weight. Those molecules which have lower molecular weight are smaller and can reach the deeper layers of the skin. They are responsible for the moisture content of the skin. The molecules with high molecular weights remain closer to the surface, provide immediate hydration, but for a long-term effect, it is advisable to use this molecular weight combined with low molecular weight hyaluronic acid.


High Molecular Weight

These molecules cannot penetrate the skin surface, but they form a layer with keratin and moisturize the skin while they also improve its elasticity. Although this layer can be washed off quickly, but it boosts your skin with instant nourishment.

Low Molecular Weight

These molecules can easily penetrate the skin. They ensure that water is stored in the skin, contributing to a long-lasting effect, so you can be sure of hydrated skin for a long time.

In this chart, you can see the types of our HyaluClearTM(hyaluronic acid), their molecular weight in Dalton and their several different uses. Below the chart, the illustrations show how different types of HA can penetrate the skin.

Type of Hyaluronic Acid

Molecular

Weight

Use
HyaluClearTMHMW
(High Molecular Weight HA)
>1..8M Da
  • Works only for a short time

  • Forms a moisturizing film on the surface of the skin

  • Has anti-inflammatory effects

HyaluClearTMMMW
(Medium Molecular Weight HA)
1.0M-1.8M Da
  • is stored in the connective tissue of the skin

  • works long term

HyaluClearTMLMW
(Low Molecular Weight HA)
100K-300K Da
  • works long term

  • is stored in the connective tissue of the skin

  • has a lasting anti-wrinkle effect

HyaluClearTM50
(Extra Low Molecular Weight HA)
25k-50k Da
  • works in deeper levels of the skin

HyaluClearTM3000

(nano HA)


3000-10000

Da

  • regenerating

  • repairing & protection from inflammation